Endocrine Abstracts

The multiple endocrine neoplasia syndromes comprise a group of heredity conditions which predispose individuals to various tumours of the endocrine glands. The conditions are inherited in an autosomal dominant fashion.Children can be affected by the conditions and it is important to recognise who is at risk because of the options of preventative strategies (MEN2) and screening to reduce morbidity (MEN1). However, genetic testing of children is problemati...

Background/objectives: We have previously shown the existence of a pancreatic islet renin-angiotensin system and its key component AT1 receptor (AT1R) was upregulated in an obese Type 2 diabetes mellitus (T2DM) mouse model. Blockade of the AT1R was found to improve beta-cell function and glucose-stimulated insulin secretion in this T2DM model. However, the mechanism(s) remain equivocal. In this context, oxidative stress was suggested to be a critical regulator for t...

HHS is a rare hyperglycaemic emergency, typically precipitated by infection in people with T2DM. There are few recorded cases of COVID induced pure HHS. We here by report 2 further cases, including the first known reported case in a person with T1DM.Case 1: 81yo male with T1DM (on glargine and aspart insulin, HbA1c 57 mmol/mol) presentedwith lethargy, general deterioration and a fall.Therewere no new symptoms offever/cough/breathlessness or change in tas...

Both of peroxisome proliferator-activated receptor gamma (PPARγ) and estrogen receptor (ER) contribute to the development of thyroid cancer. Previously, the activation of ERα was found to promote the proliferation of thyroid cancer cells, whereas activation of either ERβ or PPARγ resulted in apoptosis of thyroid cancer cells. Furthermore, a transactivation between ER and PPARγ was reported in estrogen-responsive malignancy, such as breast cancer. Howev...

Objectives: We have recently identified an islet renin-angiotensin system in the pancreas which was subjected to upregulation in an obesity-induced mouse model of Type 2 diabetes mellitus (T2DM). Blockade of the AT1 receptor (AT1R) activation in this diabetic model improves islet function. It is well known that hyperglycemia plays a pivotal role in beta-cell dysfunction and T2DM. Nevertheless, glucotoxicity-induced AT1R activation and its consequence in oxidative st...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

Background: Islet cell carcinomas are low-grade tumors originating from the islets of Langerhans. Despite the indolent nature of these tumors, metastasis is often detected upon initial diagnosis, at which point the mean survival is approximately 2 years. In this study, we aim to investigate disparities that exist in these patients and how facility variables, patient demographics, and palliative care (PC) utilization contribute to differences in survival outcomes.<p class="...

Background: Islet cell carcinoma is a rare cancer of neuroendocrine origin. There has yet to be a study analyzing the treatment type and survival outcomes in this cancer. In this study, we utilized a national database to understand the correlations between patient demographics, socioeconomic factors, modality of treatment, and survival.Methods: The National Cancer Database was queried to identify patients diagnosed with islet cell carcinoma (ICD-O-3 hist...

Hyperuricemia, results from the disorder of purine metabolism or endocrine system, leads to an inflammatory arthritis and gout. Sesame oil has been reported to have a potent anti-inflammatory effect in various animal models. The aim of the present study is to examine the therapeutic effect of sesame oil on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in air pouch in unanaesthetised Sprague–Dawley rats. Air pouch, a commonly used model for gouty ar...